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Europe ASPIRE 2016 Wave 2 Awarded Proposals in Haemophilia Research:

Tami Livnat, Sackler Faculty of Medicine, Tel-Aviv University, Israel
The anti-fibrinolytic effect of bypass agents (rFVIIa and FEIBA) in combination with replacement therapy: a rotation thromboelastometry study in whole blood of hemophilia patients with inhibitors

Szymon Janczar, Medical University of Łódź, Łódź, Poland
Analysis of F8 mutations, HLA alleles and disease-associated exonic mutations to predict coagulation factor VIII inhibitor development and pharmacokinetics in patients with haemophilia A

Europe ASPIRE 2016 Wave 1 Awarded Proposals in Haemophilia Research:


Sebastien Lacroix-Desmazes, INSERM, Paris, France
"Adjuvant effect of complement activation on the immune response to therapeutic factor VIII"

Jan Pilch, Saarland University and University Hospital, Homburg/Saar, Germany
"Macrophage phenotype as a determinant of hemophilic arthropathy"

Antonino Cannavo, Leiden University Medical Center, Leiden, The Netherlands
"Non-neutralizing antibodies against factor VIII and the risk of inhibitor development in untreated and minimally treated patients with severe hemophilia A"


Europe ASPIRE 2015 Awarded Proposals in Haemophilia Research:

Susanne Holzhauer, Charité University Medicine, Berlin, Germany

Validation of the HEAD-US ultrasound scoring system to assess joint damage in pediatric hemophilia patients with magnetic resonance imaging

Felipe Querol Fuentes, University of Valencia, Valencia, Spain

Improvement of physical fitness and quality of life related to health in haemophilia patients using sensor Kinect™ and telemedicine

Alessio Branchini, Dipartimento di Biochimica e Biologia Molecolare and LTTA Centre, Università degli Studi di Ferrara, Italy

Improved intracellular procession of protein variants as a personalized therapeutic approach for Haemophilia

Kevin Deschamps, University Hospital Leuven, Leuven, Belgium

Non-invasive in-vivo measurement of joint stresses in the foot during walking in children and adults with hemophilia: diagnostic and therapeutic efficacy


Europe ASPIRE 2014 Awarded Proposals in Haemophilia Research:

Dr. Brigitte Tardy-Poncet, St Etienne, France

Thrombin Generation Numerical Models Validation in Haemophilic Case

Dr. Goris Roosendaal, University Medical Center Utrecht, The Netherlands

The impact of a single joint bleed on cartilage matrix turnover, a human in vivo study

Dr. Sébastien Lacroix- Desmazes, Centre de Recherche des Cordeliers, France

Control of B-cell responses using btk antagonists in hemophilia A

Dr. Pieter Willem Kamphuisen University Medical Center Groningen, The Netherlands

Prevalence of mediasclerosis in peripheral arteries and its relation to hypertension in patients with Hemophilia: an exploratory study

Dr. Merel Timmer University Medical Center Utrecht, The Netherlands

Physical activity after acute intra articular bleeds in hemophilia

Dr. Osman A. El-Maarri Universitätsklinikum Bonn, Germany

Developing a DNA methylation-based method to detect rearrangements in F8

Dr. Mirko Pinotti University of Ferrara, Italy

Residual factor IX expression in Hemophilia B patients with nonsense mutations: a determinant of inhibitory development?


Europe ASPIRE 2013 Awarded Proposals in Haemophilia research:

Dr. K. Deschamps (UZ Leuven, Belgium)

Quantification of foot biomechanics in haemophilic children with ankle arthropathy through a state-of the art integrated approach

Dr. N. Enjolras (University of Lyon, France)

FAM20C - Induced recombinant FIX phosphorylation

Dr. K. Khair (Great Ormond Street Hospital for Children NHS Trust, London, UK)

Study Of physical Function In adolescenTs with haemophilia (The SO-FIT study)

Dr. R. Parra (Hospital Vall d’Hebron, Barcelona, Spain)

Development of an efficient high-throughput platform for Hemophilia A drug screening and gene correction using patient-specific induced pluripotent stem cells (iPSCs)

Prof. C.H. Toh (University of Liverpool, UK)

Haemophilic Arthropathy and the role of Extracellular Histones - An early translational approach towards preventing haemophilic arthropathy


Europe ASPIRE 2012 Awarded Proposals in Haemophilia research:

Dr. M. H. Cnossen (The Netherlands)

Targeting Rapid Implementation of Pharmacokinetic Profiling in Hemophilia

Dr. Y. Dargaud (France)

Tailoring hemophilia prophylaxis to individual patients’ needs using thrombin generation assay

Dr. M. Di Minno (Italy)

Ultrasound evaluation of arthropathy in moderate haemophilia. A multicenter study

Dr. V. Jimenez-Yuste (Spain)

Post hemarthrosis synovitis markers on patient with haemophilia on prophylaxis. Clinical, biological and ultrasonographic study

Dr. S. Rangarajan (UK)

Efficacy and cost effectiveness of standard versus pharmacokinetic dosing during factor VIII prophylaxis in adult patients with severe Haemophilia A – Pilot Study


Europe ASPIRE 2011 Awarded Proposals in Haemophilia B research:

Dr. C. Millar (Hammersmith Hospital, Imperial College, London, UK)

Improved measurement of FIX activity in recombinant and plasma concentrates by measuring thrombin generation in extrinsic and intrinsic based assays

Dr. R. Schutgens (UMC Utrecht, The Netherlands)

Variability in platelet function in relation to haemophilia B phenotype

Dr. N. Enjolras, (CHU Lyon, France)

A new strategy to produce a recombinant FIX (rFIX) with higher in vivo recovery for the treatment of haemophilia B

Prof. B. Kehrel, (University Hospital, Muenster, Germany)

Influence of cell surface chaperones, calreticulin, GRP78 (BIP) and protein disulfide isomerase (PDI) on the recovery and efficacy of Factor IX in haemophilia B


May 2017