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Awards - Vaccine Research

Competitive Research Grant Award Recipients

2014 ASPIRE Awards in Vaccines Research in Europe

Research Topic: Evaluating the Burden of Pneumococcal Disease in children and adults in European countries

Research Award Recipients

Elisa Cordero-Matia, MD, PhD

Infectious Diseases physician

University Hospital Virgen del Rocio/Institute of Biomedicine of Seville (IBiS), Spain

Prevalence and clinical impact of Streptococcus Pneumoniae nasopharyngeal carriage in solid organ transplants recipients. Dynamics of colonization, serotypes distribution, and antimicrobial resistance.

Philippe Lanotte, MD, PhD

Assistant Professor

Bacteriology-Virology Department , University Hospital Bretonneau-CHRU de Tours, France

Bacterial and viral co-infections in severe community-acquired pneumonia: analysis of predisposing factors and severity of pneumococcal infections associated or not with 26 other pathogens identified by real time multiplex PCR.

Raquel Sá-Leão DVM PhD

Associate Researcher

Laboratory of Molecular Microbiology and Human Pathogens, Instituto de Tecnologia Quimica e Biológica, Portugal

CoPneumo - Co-colonization by pneumococci in the era of the thirteen-valent pneumococcal conjugate vaccine.

Krzysztof Trzciński, DVM PhD

Associate Professor

Department of Pediatric Immunology and Infectious Diseases

Wilhelmina Children’s Hospital, University Medical Center Utrecht, Netherlands

Dynamics of Streptococcus pneumoniae carriage in infants in the era of pneumococcal conjugate vaccines.

2013 ASPIRE Investigator Awards in Adult Vaccines Research

Sylvia Becker-Dreps, MD, MPH

Assistant Professor

University of North Carolina at Chapel Hill

Streptococcus pneumoniae in Older Adults in Retirement Communities (SOAR)s

Kristin Dascomb, MD, PhD

Adjunct Assistant Professor

Intermountain Medical Center

Serotype Distribution of Pneumonia Isolates and Invasive Pneumococcal Isolates in Adults in Utah After the Introduction of PCV13 in Children and Immunocompromised Adults

Annabelle de St. Maurice, MD

Pediatric Infectious Diseases Fellow

Vanderbilt University Medical Center

Invasive Pneumococcal Disease Among Healthy and High-Risk Adults in the Post-PCV13 Era

Betsy Foxman, PhD

Hunein F. and Hilda Maassab Endowed Professor of Epidemiology

University of Michigan

Influenza Infection and Streptococcal pneumoniae Carriage

Daniel Frank, PhD

Assistant Professor

University of Colorado School of Medicine

Impact of the Human Nasopharyngeal Microbiome on Streptococcus pneumoniae Carriage in Immunocompromised Individuals

Karin Provost, DO, PhD

Research Assistant Professor

SUNY at Buffalo

Defining the Epidemiologic Burden of Streptococcus pneumoniae Colonization and Infection in Chronic Obstructive Pulmonary Disease (COPD)

Manika Suryadevara, MD

Assistant Professor

SUNY Upstate Medical University

Characterization of Nasopharyngeal Colonization of Streptococcus pneumoniae in HIV-infected Adults in Central New York Following the Introduction of Conjugate Pneumococcal Vaccine-13

2012 Awards in Antibacterial Research

Jeffrey Caterino, MD MPH

Associate Professor of Emergency Medicine and Internal Medicine

Director of Emergency Medicine Clinical Research

The Ohio State University

Tigecycline for the Treatment of Complicated Skin and Skin Structure Infections in the Setting of Advanced Age, Diabetes, and Immunosuppression: A Retrospective, Propensity Score-Adjusted Analysis

Emily Martin, MPH, PHD

Assistant Professor of Pharmacy Practice

Wayne State University

Outcomes following Linezolid Therapy in Complicated Skin and Soft Tissue Infections: A Multi-Center Retrospective Study

Kerry LaPlante, PharmD

University of Rhode Island, College of Pharmacy

Providence Veterans Affairs Medical Center

The Effects of Obesity on the Comparative Effectiveness of Linezolid and Vancomycin in MRSA Pneumonia

Usha Stiefel, MD

Assistant Professor of Medicine

Case Western Reserve University

Chief, Infectious Diseases Section

Louis Stokes Cleveland Department of Veterans Affairs Medical Center

Role of Microbial Eradication in Preventing Recurrent MRSA Infection

2012 Awards in Vaccine Research

Altreisha Nass-Sheva Foster, PhD

Research Fellow

Department of Pathology, Case Western Reserve University

University Hospitals Case Medical Center

Effect of PCV13 on Pediatric Pneumococcal Disease in Cleveland

Kerry LaPlante, PharmD

Associate Professor of Pharmacy

University of Rhode Island, College of Pharmacy

Providence Veterans Affairs Medical Center

Burden of Pneumococcal Disease in a National Cohort of Adults 50 years and Older Focus on Incidence and Prevalence of Disease Comorbidities

Kimberly Shea, PhD, MPH

Assistant Professor of Epidemiology

Boston University School of Public Health

Evaluation of Differences in S. pneumoniae Colonization Among Children With and Without Underlying Comorbidities Following the Introduction of PCV13

Steven Lawrence, MD, MSc

Assistant Professor of Medicine

Division of Infectious Diseases

Washington University School of Medicine

Effect of Medical Comorbidities on Pneumococcal Disease Burden in Older Adults: A Hospital-Based Nested Case-Control Study3

Pui-Ying Iroh Tam, MD

Assistant Professor of Pediatric Infectious Diseases

University of Minnesota,

Amplatz Children’s Hospital

Clinical Features and Outcomes of Invasive Pneumococcal Disease in Children Before and After Licensure of the 13-valent Pneumococcal Conjugate Vaccine

Subhashis Mitra, MD

Assistant Professor of Medicine

Division of Infectious Diseases

Michigan State University

Streptococcus pneumoniae Colonization and Immunogenicity of 13-valent Conjugate Pneumococcal Vaccine in Patients 50 Years or Older with End Stage Renal Disease on Dialysis

2011 – Pulmonary Vascular Disease Research

Research Topic: Evaluation of pulmonary vascular disease mechanisms and outcomes

Research Award Recipients: Young/Junior Investigators

Hyung J. Chun, MD

Yale University

Targeting of p53 by MicroRNAs in the Pulmonary Endothelium: Implications in Pulmonary Arterial Hypertension

Corey Ventetuolo, MD

Rhode Island Hospital

Sex Hormones and Genetic Determinants of Right Ventricular Structure and Function: The MESA-RV Study

Tim Lahm, MD

Indiana University

Compartment-specific and Estrogen Receptor-beta Dependent Effects of 17-Estradiol on Pulmonary Vascular and Right Ventricular Remodeling in Angioproliferative Pulmonary Hypertension

2011 – Antibacterial Research

Research Topic: MRSA Clinical Research in Specific Patient Populations and Infection Types

Research Award Recipients: Young/Junior Investigators

Ganapathi Parameswaran, MB, BS

Research Assistant Professor

Division of Infectious Diseases

VA Western New York Healthcare System

Methicillin resistant Staphylococcus aureus infection in COPD and effects of linezolid treatment on inflammation

Michael David, MD, PhD

Section of Infectious Diseases and Global Health

Department of Medicine

The University of Chicago

Asymptomatic colonization with S. aureus after therapy with linezolid or clindamycin for acute S. aureus skin and skin structure infections in patients with comorbid conditions: A randomized trial

Delores (Ching Wen) Tseng, PhD

Research Scientist I

Division of Pediatric Infectious Diseases

Cedars-Sinai Medical Center

Effect of linezolid versus vancomycin on treatment of MRSA sepsis in aged hosts

Research Topic: Basic and Translational Research to Understand the Impact of Antimicrobials on Endogenous Gastrointestinal Microflora

Michael Aldape, PhD

Associate Research Scientist

Infectious Diseases Research Group

VA Medical Center, Boise, ID

Targeting the inflammatory response during Clostridium difficile infection with tigecycline

David Haslam, MD

Associate Professor

Department of Pediatric and Molecular Microbiology

Washington University School of Medicine

Investigating the prevalence of CA-MRSA as a cause of skin and soft tissue infections in the South London community and potential phenotypic, genotypic and functional differences with colonising CA-MRSA strains

Louis-Charles Fortier, PhD

Assistant Professor
Department of Microbiology and Infectious Diseases

Université de Sherbrooke

Study on how tigecycline affects the microbiota and bile acid composition of the gut and how it impacts Clostridium difficile lifestyle and susceptibility to Clostridium difficile infection

Amee R. Manges, MPH PhD

Associate Professor

Department of Epidemiology,

Biostatistics and Occupational Health Associate Member

Department of Microbiology and Immunology

McGill University

Antimicrobial use, intestinal microbiota and Clostridium difficile colonization and infection in hospitalized patients

Saul Tzipori, DVM, PhD

Distinguished Professor

Department of Biomedical Sciences

Tufts University Cummings School of Veterinary Medicine

Evaluate the impact of tigecycline on Clostridium difficile infection in a newly developed animal model with normal human gut microflora

Vincent B. Young, MD, PhD

Associate Professor

Department of Internal Medicine/Infectious Diseases Division

Department of Microbiology and Immunology

The University of Michigan

Effects of tigecycline on the murine intestinal microbiome and experimental Clostridium difficile infection

2010 – Antibacterial Research

United States & Canada

Research Topic: Post-Influenza Bacterial Pneumonia: Disease Pathogenesis, Host Response and Impact of Antibacterial Therapy Including Linezolid

Research Award Recipients - Young Investigators

Urvashi Bhan, MD

University of Michigan

Linezolid for the treatment of murine post influenza

cMRSA pneumonia

Tanyalak Parimon, MD

Infectious Disease Laboratory Research, Boise ID

The effect of linezolid upon extracellular toxin suppression and the formation of platelet / neutrophil aggregates induced lung necrosis in a murine post-influenza MRSA pneumonia model

Dawn Bowdish, PhD

McMaster University

Intranasal administration of Linezolid to prevent seasonal & post-influenza pneumococcal pneumonia in the elderly

Marin Schweizer, MD

University of Iowa Carver College of Medicine

Linezolid Therapy and Outcomes in Patients with Post-Influenza Staphylococcus aureus Pneumonia, Controlling for Patient, Pathogen and Treatment Characteristics

Jane Deng, MD

David Geffen School of Medicine at UCLA

Effect of linezolid on postinfluenza dysregulation of

antibacterial responses

Marin Schweizer, MD

University of Iowa Carver College of Medicine

Linezolid Therapy and Outcomes in Patients with Post-Influenza Staphylococcus aureus Pneumonia, Controlling for Patient, Pathogen and Treatment Characteristics

David Feola, PharmD, PhD

University of Kentucky

Impact of linezolid's suppression of interferon-gamma upon immune hyporesponsiveness after influenza infection

 

Europe

2010 Research Topic: Epidemiology of CA-MRSA in Europe and the Role of Linezolid for the Treatment of Infections Due to CA-MRSA

Research Award Recipients

Karsten Becker, MD

University Hospital Münster, Germany

Prevalence of community-acquired and livestock-associated MRSA in the Dutch-German EUREGIO

Gary French BSc, MD, FRCPath, DipHIC

Kings College London, UK

Investigating the prevalence of CA-MRSA as a cause of skin and soft tissue infections in the South London community and potential phenotypic, genotypic and functional differences with colonising CA-MRSA strains

Albert Pahissa Berga, MD

Hospital Vall d’Hebron, Spain

Impact of linezolid, alone or associated to other antimicrobials, on the production of Panton-Valentine Leukocidin and on the outcome of experimental necrotizing pneumonia produced by community-acquired Staphylococcus aureus

Kurt Fuursted, MD

University of Aarhus, Denmark

The use of Caenorhabditis elegans and Panagrellus redivivus as a host-pathogen models for community-associated methicillin-resistant S. aureus (CA-MRSA) : Evaluation of virulence determinants during colonization versus infection

Alain Bizzini, MD, PhD

CHUV Lausanne, Switzerland

Detection and surveillance of heteroresistance in community-associated methicillin-resistant Staphylococcus aureus

(CA-MRSA) by isothermal microcalorimetry

Stephan Harbarth, MD

University Hospitals and Medical School, Switzerland

Community-associated MRSA in Europe: multiresistance, virulence and patient risk profiles – a collaborative project

Emilio Bouza Santiago, MD, PhD

Hospital G.U. Gregorio Marañon, Spain

Clinical and molecular epidemiology of methicillin resistant community- acquired Staphylococcus aureus in Spain

Brian Kristensen, MD, PhD

Aarhus University Hospital, Denmark

Decolonization strategies for community-acquired MRSA: Early contact with either prompt or delayed intervention

Delphine Croisier-Bertin, PharmD, PhD

CHU Dijon, France

Evaluation of the antibacterial/antitoxinic activity of a linezolid humanequivalent dosage in a severe Panton Valentine Leukocidin pneumonia model

Frédéric Laurent, PharmD, PhD

University of Lyon, France

Evolutionary history of the European ST80 CA-MRSA clone based on high-throughput genomics approach

N. Frederik Dagnaes-Hansen, DVM PhD

University of Aarhus, Denmark

In vitro and in vivo activity of tigecycline, linezolid and vancomycin alone or in combination with rifampicin on community-aquired methicillin resistant Staphylococcus aureus: The significance of evaluating both the anti-bacterial and anti-biofilm effect.

Marco Ranieri, MD

Torino Hospital University, Italy

CA-MRSA in Turin, Italy: Molecular Characterization and Pharmacokinetic of Linezolid in the ICU

Oana Dumitrescu, MD, PhD

University of Lyon “Claude Bernard”, France

Cooperation between antibiotics and the innate immune system mediators against community acquired meticillin resistant

S. aureus (CA-MRSA)

 

2010 – Pulmonary Vascular Disease Research

United States & Canada

Research Topic: Evaluation of pulmonary vascular disease mechanisms and outcomes

Research Award Recipients

Hubert Chen, MD

University of California, San Francisco

Development of a New Patient-Reported Activity-Based Measure of Functional Status for Patients with Pulmonary Arterial Hypertension

Greg Lewis, MD, MSc

Massachusetts General Hospital, Harvard School of Medicine

Right Ventricular-Pulmonary Vascular Coupling in Pulmonary Hypertension

Brian Graham, MD

University of Colorado Denver

Intranasal administration of Linezolid to prevent seasonal & post-influenza pneumococcal pneumonia in the elderly

Marc Simon, MD, MSc

University of Pittsburgh

Right Ventricular Regional Contractile Response to Pulmonary Vascular Disease

Anna Hemnes, MD

Vanderbilt University School of Medicine

End Tidal Carbon Dioxide: A Biomarker in Pulmonary Arterial Hypertension

 

2009 – Antibacterial Research

United States

Research Topic:In vitro, in vivo, and clinical investigations of linezolid’s role in modulating Gram-positive pathogens specifically MRSA pathogenesis and host-pathogen interactions

Research Award Recipients

Morohunfolu Akinnusi, MD

Clinical Assistant Instructor

Department of Medicine

University at Buffalo

m59a@buffalo.edu

Linezolid Modulation of Lung Innate Immunity in a Murine Model of MRSA Pneumonia

George Liu, M.D., Ph.D.

Assistant Professor of Pediatrics, Division of Pediatric Infectious Diseases and the Immunobiology Research Institute

Cedars-Sinai Medical Center David Geffen School of Medicine at The University of California, Los Angeles

george.liu@cshs.org

Effect of Linezolid on Panton-Valentine Leukocidin Mediated Tissue Injury

Natalie Boyd, M.S., Pharm.D.

Research Scientist, Lecturer

College of Pharmacy

University of New Mexico

nboyd@salud.unm.edu

Linezolid-mediated potentiation of host defense efficacy against MRSA and MSSA

Govindarajan Rajagopalan, Ph.D.

Assistant Professor, College of Medicine

Mayo Clinic

rajagopalan.govindarajan@mayo.edu

Effect of Linezolid on S. aureus Superantigen Production and Immune Activation In vivo and In vitro

Jiwang Chen Ph.D.

Research Assistant Professor

Division of Pulmonary & Critical Care Medicine

Northwestern University

jiwang@northwestern.edu

Linezolid Benefit in CA-MRSA Pneumonia: Toxin Suppression vs Host Immunomodulation

Eric Skaar, Ph.D.

Assistant Professor of Microbiology and Immunology

School of Medicine

Vanderbilt University

eric.skaar@Vanderbilt.edu

Imaging the impact of linezolid on bacterial abscess dynamics using magnetic resonance

Binh Diep, Ph.D.

Instructor, Department of Medicine

University of California San Francisco

bdiep@medsfgh.ucsf.edu

Linezolid vs. Vancomycin for Treatment of Necrotizing Pneumonia Caused by PVL-producing CA-MRSA

Brian Tsuji, Pharm.D.

Assistant Professor

School of Pharmacy and Pharmaceutical Sciences

University at Buffalo

btsuji@buffalo.edu

Impact of Linezolid on MRSA Accessory Gene Regulator (agr) Profiling Pharmacodynamics and RNAIII

Apoorv Kalra, M.D.

Assistant Professor of Medicine

Michigan State University

kalra@msu.edu

Effect of Linezolid on factors influencing S. aureus adherence and invasion of human cells